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Corneal Collagen Crosslinking FAQs

Q. How does Corneal Collagen Crosslinking (CXL/KXL) work?

A. The combination of UV light exposure to a cornea soaked in vitamin B2, riboflavin, creates new bonds within the cornea causing it to stiffen and become stronger. A single treatment is usually all that is required to achieve this effect and halt the progression of keratoconus.

Q. What is Keratoconus? How do I know if I have it?

A. Keratoconus is a disease of increasing near-sightedness (myopia) and astigmatism (irregular and steep corneal shape) that is due to weakening of the cornea. Over time, the weakened cornea can take on a conical shape, giving this disease its name. This process typically begins in adolescence or young adulthood.

Many patients are unaware that they have the disease, but find that their vision keeps worsening and that they continually need stronger and stronger glasses, or even hard contact lenses to see well. Many experience difficulty with glare and night vision. Eye rubbing is often associated with this condition.

If you are someone who rubs your eyes a lot and has increasing astigmatism, you should be examined to determine if you have this disease. While it can run in families, most patients do not have family members with this condition.

To determine if you have this disorder a corneal topography, or surface map, is needed to examine the shape of the cornea. With such mapping, the diagnosis can definitively be made by your ophthalmologist.

Q. Is Corneal Collagen Crosslinking (CXL/KXL) effective?

A. Multiple clinical studies since 2003 have demonstrated the effectiveness of CXL in halting the progression of vision loss from keratoconus. The technology has been in wide spread use around the world, including throughout Europe where it received the CE Mark of approval in 2006. A decade later, the rigorous stamp of FDA approval was given on April 18, 2016.

Studies show that CXL is effective for the majority of patients in stopping vision loss from keratoconus. Additionally, some patients will experience an improvement in vision due to a decrease in corneal steepening and myopia.

Q. Is Corneal Collagen Crosslinking (CXL/KXL) safe?

A. Yes. However, just like any other treatment there are risks to this surgical procedure. You should have an informed discussion about the safety and appropriateness of this procedure with your ophthalmologist before undergoing the treatment.

A full list of the adverse reactions from the Avedro FDA clinical study can be found in their labeling information here.

Q. Is CXL covered by insurance?

A. We are finally at the point that most insurers are still covering this procedure in full in the region! 

If you are losing vision from progressive keratoconus, you should have your eye treated as soon as possible. Remember, CXL halts the progression of disease but it cannot fully reverse it. Waiting may result in a permanent change to your cornea that significantly worsens your quality of vision.

Q. What should I expect with the CXL procedure?

A. The procedure itself takes approximately 1 hour and is painless. However, there will be discomfort and blurriness during a period following the procedure typically lasting about 5 days (each patient’s experience will vary). Every patient must be seen at least twice during the week following the procedure. During this period, you will be placed in a bandage contact lens and will not be able to wear your own contact lenses in the operative eye.

During your pre-surgical consultation, your surgeon will provide you with more details regarding what to expect with the procedure and the healing period.

To schedule an appointment to determine if you qualify for CXL, call 215-339-8100 and ask for a corneal consultation for keratoconus with Dr. Brad H Feldman

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